SLC6A4 5HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome
نویسندگان
چکیده
منابع مشابه
Metabolic Syndrome in Patients with Polycystic Ovary Syndrome in Iran
Background The prevalence of metabolic syndrome (MetS) in polycystic ovary syndrome (PCOS) has been studied in different populations, but their results were so controversial regarding Iranian women. These controversial data indicated the need for more investigation of MetS characteristics in PCOS patients in our population. So this study aimed to evaluate the clinical and laboratory characteris...
متن کاملP-212: Ala 307 Thr Polymorphism of FSHR in Iranian Patients with Polycystic Ovary Syndrome (PCOS)
Background: Follicle stimulating hormone (FSH) receptor plays an important role in FSH signaling during reproductive development. Any changes in FSHR gene is resulted in alteration of amino acid in protein chain, consequence to affect the binding affinity, intracellular signaling and expression levels of FSHR. FSHR polymorphisms can be involved in etiology of many reproductive disorders such as...
متن کاملInsulin resistance in patients with polycystic ovary syndrome.
With a prevalence of 5%-10% the polycystic ovary syndrome (PCOS) is an exceptionally common disorder of premenopausal women. According to prospective studies, women with PCOS present abnormal glucose tolerance and diabetes mellitus in 31%-35% and 7.5%-10%, respectively. PCOS patients have a higher prevalence of cardiovascular risk factors such as hypertension, type 2 diabetes and dyslipidaemia....
متن کاملInsulin Secretory Defects in Polycystic Ovary Syndrome
The increased prevalence of non-insulin-dependent diabetes mellitus (NIDDM) among women with polycystic ovary syndrome (PCOS) has been ascribed to the insulin resistance characteristic of PCOS. This study was undertaken to determine the role of defects in insulin secretion as well as familial factors to the predisposition to NIDDM seen in PCOS. We studied three groups of women: PCOS with a fami...
متن کاملInsulin-sensitising agents in polycystic-ovary syndrome.
Insulin-sensitizing agents have been recently proposed as the therapy of choice for polycystic ovary syndrome (PCOS), since insulin resistance and associated hyperinsulinemia are recognized as important pathogenetic factors of the syndrome. Moreover, since almost all obese PCOS women and more than half of those of normal weight are insulin resistant, and therefore present some degree of hyperin...
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ژورنال
عنوان ژورنال: International Journal of Endocrinology
سال: 2018
ISSN: 1687-8337,1687-8345
DOI: 10.1155/2018/6130487